CCT in Anaesthetics - Stage 1 Training

Published: 22/10/2024

General Anaesthesia (GA)

1_GA_A: Conducts comprehensive pre-anaesthetic and pre-operative checks 

1_GA_A_1  Describes the need for a targeted and relevant clinical examination
1_GA_A_2 Describes the basis for clinical signs and the relevance of positive and negative physical signs
1_GA_A_3  Anaesthetic history taking
1_GA_A_4  Recognises that patients do not always present history in a structured fashion
1_GA_A_5  Lists the likely causes and risk factors for conditions relevant to mode of presentation
1_GA_A_6  Uses the patient’s agenda and history to inform examination, investigation and management
1_GA_A_7  Indications for rapid sequence induction
1_GA_A_8  Specific complications of anaesthetic drugs including anaphylaxis, suxamethonium apnoea and malignant hyperpyrexia; prediction of patients who are at increased risk of these complications
1_GA_A_9  Risk factors for post-operative nausea and vomiting
1_GA_A_10 

Obtains a history specifically relevant to the planned anaesthesia and surgery including:

A history of the presenting complaint for surgery

A systematic comprehensive relevant medical history

Information about current and past medication

Drug allergy and intolerance

Information about previous anaesthetics and relevant family history

1_GA_A_11

Performs a relevant clinical examination including when appropriate:

Cardiovascular system

Respiratory system

Central and peripheral nervous system

Airway assessment

1_GA_A_12 Factors that influence the risk of gastric reflux/aspiration and strategies to reduce it


1_GA_B: Safely manages induction and maintenance of anaesthesia by inhalational and intravenous techniques, extubation and emergence from anaesthesia

1_GA_B_1 Gives examples of methods of anaesthesia that are suitable for common operations.  
1_GA_B_2 Indications for pre-medication
1_GA_B_3

Makes appropriate plans for anaesthesia: 

Reviews current medication and seeks advice where appropriate 

Plans appropriate anaesthetic technique[s] 

Secures consent for anaesthesia 

Recognises the need for additional investigation and acts accordingly 

Discusses issues of concern with relevant members of the team 

1_GA_B_4 Explains the importance of maintaining the principles of aseptic practice and minimising the risks of hospital acquired infection
1_GA_B_5 Principles of management of the airway including maintenance of a clear airway and the use of airway adjuncts and supraglottic airway devices
1_GA_B_6 Advantages and disadvantages of intubation and supraglottic airway devices for airway management during anaesthesia
1_GA_B_7 Different types of supraglottic devices
1_GA_B_8

Indications for tracheal intubation:

Types of tracheal tube and identifies their applications 

Choice of the correct size and length of tracheal tube 

Advantages/disadvantages of different types of laryngoscopes and blades including, but not exclusively, the Macintosh and McCoy and videolaryngoscope 

Confirmation of correct placement of a tracheal tube; identification and complications of endobronchial or oesophageal intubation 

Confirmation of correct placement of a tracheal tube; identification and complications of endobronchial or oesophageal intubation 

Management of difficult intubation and failed intubation 

Identification of patients who are at increased risk of regurgitation and pulmonary aspiration; measures that minimise the risk 

1_GA_B_9 Rapid sequence induction of anaesthesia
1_GA_B_10 Indication and techniques for fibre-optic intubation
1_GA_B_11 Problems associated with limb tourniquets and their safe use
1_GA_B_12 Hazards associated with positioning – supine, lateral, prone, sitting
1_GA_B_13 Anaesthesia for surgery in the prone and lateral positions
1_GA_B_14 Blood conservation in major surgery
1_GA_B_15 Surgical procedures for managing hip fractures, the anaesthetic requirements for each and the current evidence for the choice of anaesthetic technique
1_GA_B_16

Pathophysiology, diagnosis and management of specific orthopaedic surgical complications that are relevant to anaesthesia including but not exclusively

  • Bone cement Implantation Syndrome
  • Diagnosis and management of fat embolism
  • Upper and lower limb compartment syndrome
1_GA_B_17 Anaesthetic techniques appropriate for day cases including appropriate drugs
1_GA_B_18 Pre-oxygenation, effects, limitations and correct techniques for its use
1_GA_B_19 Intravenous and inhalational induction; techniques, advantages and disadvantages of both
1_GA_B_20 Factors influencing the choice of agent for inhalational or intravenous induction of anaesthesia
1_GA_B_21 Non anaesthetic physiological effects of intravenous and inhalational induction
1_GA_B_22 Identifies the special problems of induction associated with cardiac disease, respiratory disease, musculoskeletal disease, obesity and those at risk of regurgitation/pulmonary aspiration
1_GA_B_23 Removal of tracheal tubes and supraglottic airway devices and associated complications
1_GA_B_24 Tracheal extubation strategies and management of laryngospasm at extubation
1_GA_B_25 Physical and physiological effects of laparoscopic surgery including the effects of positioning (eg Trendelenberg, reverse Trendelenberg)


1_GA_C: Plans recovery care, and manages recovery from anaesthesia utilising safe discharge criteria 

1_GA_C_1 Indications for, contra-indications to and complications of oxygen therapy in the post-operative period
1_GA_C_2 Techniques for administration of oxygen therapy and performance characteristics of available devices
1_GA_C_3 Identification and management of respiratory complications seen in recovery
1_GA_C_4 Identification and management of cardiovascular complications seen in recovery
1_GA_C_5 Identification and management of other common complications seen in recovery
1_GA_C_6 Monitoring and the frequency of observations required for patients having undergone different types of surgery
1_GA_C_7 Care of an unconscious patient in the recovery room, including safe positioning
1_GA_C_8 Patient factors possibly requiring higher levels (level 2 or 3) of care in the postoperative period
1_GA_C_9 Lists the appropriate discharge criteria for patients leaving the recovery room and for day stay patients
1_GA_C_10 Explains the importance of following up patients in the ward after surgery
1_GA_C_11 Principles of postoperative fluid regimes including volumes, types of fluid and monitoring of fluid balance


1_GA_D: Diagnoses and manages common peri-operative complications

1_GA_D_1 Contribution of PONV to post-operative outcomes and satisfaction
1_GA_D_2 Predisposing factors for PONV
1_GA_D_3 Regimes for prevention and treatment of PONV
1_GA_D_4 Recognition and management of incomplete reversal of neuromuscular blockade
1_GA_D_5 Causes and management of postoperative confusion
1_GA_D_6 Causes and management of postoperative hypo and hypertension
1_GA_D_7 Prevention, diagnosis and management of postoperative pulmonary atelectasis
1_GA_D_8 Causes and management of stridor
1_GA_D_9 Signs of pulmonary aspiration and its emergency management


1_GA_E: Recognises anaesthetic critical incidents and explains their causes and management

1_GA_E_1 Unexpected fall in SpO2
1_GA_E_2 Unexpected increase in peak airway pressure
1_GA_E_3 Progressive fall in minute volume during spontaneous respiration or IPPV
1_GA_E_4 Fall in end tidal CO2
1_GA_E_5 Rise in end tidal CO2
1_GA_E_6 Rise in inspired CO2
1_GA_E_7 Unexpected hypotension
1_GA_E_8 Unexpected hypertension
1_GA_E_9 Arrythmias
1_GA_E_10 Convulsions
1_GA_E_11 Regurgitation or aspiration of stomach contents
1_GA_E_12 Laryngospasm
1_GA_E_13 Difficulty with IPPV, sudden or progressive loss of minute volume
1_GA_E_14 Bronchospasm
1_GA_E_15 Pneumothorax and tension pneumothorax
1_GA_E_16 Gas, fat and pulmonary embolism
1_GA_E_17 Adverse drug reactions
1_GA_E_18 Anaphylactic reactions and the appropriate management including follow up and patient information
1_GA_E_19 Transfusion reactions (major and minor), management of inadvertent transfusion of mis-matched blood or blood products
1_GA_E_20 Inadvertent intra-arterial injection of irritant fluids
1_GA_E_21 High or total spinal block
1_GA_E_22 Local anaesthetic toxicity
1_GA_E_23 Accidental decannulation of tracheostomy or tracheal tube
1_GA_E_24 Brain stem herniation due to increased intracranial pressure
1_GA_E_25 Malignant hyperpyrexia
1_GA_E_26 Awareness of the importance of critical incident reporting
1_GA_E_27 The provision of information to the patient and where necessary ensuring that they get the appropriate counselling and advice with appropriate supervision
1_GA_E_28 The need to follow through a critical incident with proper reporting, presentation at morbidity meetings and warning flags as necessary


1_GA_F: Demonstrates knowledge of standard equipment used in anaesthetic practice with an understanding of relevant underpinning physics and clinical measurement involved

F1: Equipment

1_GA_F1_1 The functions and safety features of the anaesthetic machine
1_GA_F1_2 Patient warming systems: principles
1_GA_F1_3 Warming equipment for intravenous fluids: principles
1_GA_F1_4 Storage of gases and vapours including safety
1_GA_F1_5 Suction devices
1_GA_F1_6 Scavenging devices
1_GA_F1_7 Cylinders and pipelines, Bourdon gauge
1_GA_F1_8 Vaporisers: principles including plenum and draw over, temperature compensation, calibration
1_GA_F1_9 Electrical hazards: causes and prevention
1_GA_F1_10 Electrocution: including microshock, earth faults, leakage
1_GA_F1_11 Electrical equipment safety: medical, classification, types of equipment, symbols
1_GA_F1_12 ECG: principles including electrodes and electrode placement
1_GA_F1_13 Lasers: basic principles and safety
1_GA_F1_14 Cardiac pacemakers: Classification and safety
1_GA_F1_15 Defibrillators and defibrillation: principles including thoracic impedance, implantable devices
1_GA_F1_16 Diathermy: monopolar, bipolar; safety and uses
1_GA_F1_17 Plenum systems: warming blankets, theatre and anaesthetic room ventilation
1_GA_F1_18 Breathing systems: Mapleson classification, coaxial systems, circle systems, Tpiece, resuscitation breathing devices
1_GA_F1_19 Ventilators: principles including pressure and flow generators, cycling, jet and oscillator ventilators
1_GA_F1_20 Disconnections: monitoring of ventilator disconnection, warning devices
1_GA_F1_21 Fires and explosions: risks and prevention
1_GA_F1_22

Infusion pumps and syringe drivers; PCA devices, epidural infusion devices.

Principles, use, safety and relevant drug calculations

1_GA_F1_23 Principles of hygiene including disinfection and sterilisation of equipment
1_GA_F1_24 Methods of decontamination, disinfection and sterilisation
1_GA_F1_25 Describes the benefits and limitations of technology and equipment in maintaining patient safety


F2: Physics

1_GA_F2_1 SI units: fundamental and derived units
1_GA_F2_2 SI and non SI units relevant to anaesthesia including mmHg, bar, atmospheres, cm H2O, PSI
1_GA_F2_3 Simple mechanics: mass, force, work, energy, power where these are relevant to anaesthetic practice
1_GA_F2_4 Heat: including temperature, absolute zero
1_GA_F2_5 Heat transfer and loss with relevance to clinical anaesthesia: conduction, convection, radiation and evaporation
1_GA_F2_6 Latent heat
1_GA_F2_7 Colligative properties: relevance of the concepts of osmolarity, osmolality and diffusion to anaesthetic practice
1_GA_F2_8

Physics of gases. Gas laws: kinetic theory of gases, Boyle’s, Henry’s, Dalton’s,

Charles’ and Gay-Lussac’s

1_GA_F2_9 Critical temperature and pressure
1_GA_F2_10 Physics of vapours
1_GA_F2_11 Pressure; absolute and relative pressure, gauge pressure
1_GA_F2_12 Principles of laminar and turbulent flow; Hagen-Poiseuille equation, Reynold’s number
1_GA_F2_13 Relevance of gas density and viscosity. Examples including helium
1_GA_F2_14 Bernoulli principle
1_GA_F2_15 Venturi effect and entrainment devices
1_GA_F2_16 Vapour pressure; saturated vapour pressure
1_GA_F2_17 Vaporisation; process of vaporisation
1_GA_F2_18 Principles of surface tension
1_GA_F2_19 Capacitance, inductance
1_GA_F2_20 Ultrasound: basic principles of ultrasound
1_GA_F2_21 Physics relevant to optical fibres
1_GA_F2_22 Doppler effect: principle and clinical application
1_GA_F2_23 Resonance, damping, frequency response and their relevance to monitoring systems used in anaesthetic practice


F3: Clinical measurement

1_GA_F3_1 Basic measurement concepts relevant to understanding of monitoring in anaesthesia: linearity, drift, hysteresis, signal to noise ratio, static and dynamic response
1_GA_F3_2 Temperature measurement including mercury, alcohol, infrared, thermistor, thermocouple, Bourdon gauge, liquid crystal
1_GA_F3_3 Anatomical sites used for temperature measurement
1_GA_F3_4 Measurement of lung volumes and diffusion
1_GA_F3_5 Measurement of volume and flow in gases and liquids including pneumotachograph and other respirometers
1_GA_F3_6 Electrical interference; souces, methods of reduction
1_GA_F3_7 Pressure transducers
1_GA_F3_8 Capnography
1_GA_F3_9 Pulse oximetry
1_GA_F3_10 Measurement of gas pressures
1_GA_F3_11 Blood pressure: direct and indirect measurement including complications
1_GA_F3_12 Cardiac output: principles of measurement
1_GA_F3_13 Principles of measurement of pH, PCO2, PO2, electrolytes
1_GA_F3_14 Derived blood gas variables eg bicarbonate measures, base excess, oxygen consumption, respiratory quotient
1_GA_F3_15 Measurement of gas and vapour concentrations; including infrared, paramagnetic, fuel cell, oxygen electrode, mass spectrometry
1_GA_F3_16 Simple tests of pulmonary function: peak flow rate, spirometry
1_GA_F3_17 Assessment of neuromuscular blockade; quantitative and qualitative
1_GA_F3_18 Environmental monitoring; contamination by anaesthetic gases and vapours
1_GA_F3_19 Basic function and purpose of monitors
1_GA_F3_20 Minimum monitoring standards and indications for additional monitoring
1_GA_F3_21 Principles of calibration of monitoring equipment
1_GA_F3_22 Understanding the limits of monitoring equipment
1_GA_F3_23 CO2 absorption: chemistry and complications
1_GA_F3_24 Principles of measurement of parameters such as haemoglobin, blood glucose and coagulation using near-patient testing devices


1_GA_G: Demonstrates knowledge of anatomy, physiology, biochemistry and pharmacology relevant to anaesthetic practice

G1: Anatomy

1_GA_G1_1 Mouth, nose, pharynx, larynx, trachea, main bronchi, segmental bronchi, structure of the bronchial tree; age related changes from the neonate to the adult
1_GA_G1_2 Airway/respiratory tract blood supply and innervation
1_GA_G1_3 Pleura, including surface anatomy, mediastinum and its contents
1_GA_G1_4 Lungs: lobes and microstructure of lungs
1_GA_G1_5 Diaphragm, other muscles of respiration including innervation
1_GA_G1_6 The thoracic inlet and first rib; interpretation of the normal adult chest X ray
1_GA_G1_7 Heart: chambers, valves, conducting system and pericardium, blood supply and innervation
1_GA_G1_8 Great vessels, main peripheral arteries and veins
1_GA_G1_9 Brain and its subdivisions; blood supply
1_GA_G1_10 Spinal cord, structure of spinal cord, major ascending and descending pathways and blood supply
1_GA_G1_11 Anatomical organisation of pain and sensory pathways from the periphery to the central nervous system
1_GA_G1_12 Pain pathways relevant to the stages of obstetric labour and delivery
1_GA_G1_13 Spinal meninges, subarachnoid and extradural space, contents of extradural space
1_GA_G1_14 Anatomy of CSF system
1_GA_G1_15 Spinal nerves; dermatomes and applied knowledge of dermatomes in regional anaesthesia
1_GA_G1_16 Brachial plexus; nerves of the upper limb
1_GA_G1_17 Intercostal nerves
1_GA_G1_18 Nerves of the abdominal wall including innervation of the inguinal region
1_GA_G1_19 Lumbar and sacral plexuses; nerves of the lower limb
1_GA_G1_20 Anatomical organisation of the autonomic nervous system
1_GA_G1_21 Sympathetic innervation, sympathetic chain, ganglia and plexuses
1_GA_G1_22 Parasympathetic innervation; cranial and sacral outflow
1_GA_G1_23 Stellate ganglion
1_GA_G1_24 Cranial nerves
1_GA_G1_25 Innervation of the pharynx and larynx
1_GA_G1_26 Eye and orbit
1_GA_G1_27 Functional anatomy of the hypothalamic/pituitary system
1_GA_G1_28 Functional anatomy of the adrenal gland
1_GA_G1_29 Functional anatomy of the thyroid and parathyroid glands
1_GA_G1_30 Cervical, thoracic and lumbar vertebrae
1_GA_G1_31 Sacrum, sacral hiatus
1_GA_G1_32 Ligaments of the vertebral column where relevant to anaesthetic practice
1_GA_G1_33 Surface anatomy of vertebral spaces; length of the spinal cord and subarachnoid space, age related differences from the neonate to the adult
1_GA_G1_34 Structures in the antecubital fossa
1_GA_G1_35 Structures in the axilla
1_GA_G1_36 Large veins of the neck. Anterior triangle of the neck: surface anatomy and ultrasound demonstrated anatomy relevant to insertion of central venous cannulae
1_GA_G1_37 Large veins of the leg; femoral triangle
1_GA_G1_38 Arteries of upper and lower limbs
1_GA_G1_39 Landmarks for performance of cricoid pressure and surgical airway procedures
1_GA_G1_40 Landmarks for the insertion of intercostal drainage catheters and needle decompression of pneumothorax


G2: Physiology

1_GA_G2_1 Organisation of the human body and the control of the internal environment
1_GA_G2_2 Changes with advancing age
1_GA_G2_3 Cells: components and organelles
1_GA_G2_4 Function of cells: genes and their expression
1_GA_G2_5 Cell membrane characteristics; cell junctions, receptors
1_GA_G2_6 Protective mechanisms of the body
1_GA_G2_7 Definition of pH, strong and weak acids
1_GA_G2_8 Acid base balance; buffers, Henderson Hasselbach equation and anion gap
1_GA_G2_9 Ions eg Na+, K+, Mg2+, Ca2+, Cl-, HCO3-
1_GA_G2_10 Cellular metabolism; aerobic vs anaerobic
1_GA_G2_11 Fetus: physiological changes at birth
1_GA_G2_12 Enzymes
1_GA_G2_13 Capillary dynamics and interstitial fluid; osmosis, filtration and convection
1_GA_G2_14 Osmolarity; osmolality, partition of fluids across membranes, tonicity
1_GA_G2_15 Lymphatic system
1_GA_G2_16 Special fluids: CSF, pleural, pericardial, peritoneal
1_GA_G2_17 Active cellular transport mechanisms
1_GA_G2_18 Blood: physical properties, components, functions
1_GA_G2_19 Red blood cells: production and turnover, haematinics, haemoglobin and its variant including abnormal haemoglobins
1_GA_G2_20 Anaemia; acute and chronic adaptations, iron absorption, transportation and metabolism
1_GA_G2_21 Polycythaemia: causes and implications
1_GA_G2_22 Blood groups: ABO, Rhesus, others
1_GA_G2_23 Transfusion reactions; Rhesus incompatibility
1_GA_G2_24 Haemostasis and coagulation, fibrinolysis. Abnormalities, congenital and acquired
1_GA_G2_25 Alternative oxygen carrying solutions
1_GA_G2_26 White blood cells: types, origins, characteristics, turnover
1_GA_G2_27

The inflammatory response, systemic inflammatory responses, hypersensitivity reactions. Immunity and allergy: innate vs acquired, non-specific vs specific,

humoral vs cellular. Immunodeficiency – congenital and acquired

1_GA_G2_28 Action potential generation and transmission
1_GA_G2_29 Neuromuscular junction and transmission, motor end-plate
1_GA_G2_30 Disturbances of neuromuscular transmission
1_GA_G2_31 Myopathies, congenital and acquired
1_GA_G2_32 Muscle contracture: malignant hyperthermia, myoclonus, burns
1_GA_G2_33 Muscle types: skeletal, smooth, cardiac
1_GA_G2_34 Skeletal muscle excitation-contraction coupling
1_GA_G2_35 Smooth muscle contraction; sphincters
1_GA_G2_36 Motor unit concept
1_GA_G2_37 Cardiac muscle contraction
1_GA_G2_38 Cardiac cycle: pressure volume relationships, work and power
1_GA_G2_39 Rhythmicity of the heart; cardiac impulse generation
1_GA_G2_40 Regulation of cardiac function; general and cellular
1_GA_G2_41 Control of cardiac output; Starling relationship
1_GA_G2_42 Fluid challenge and heart failure, types of shock
1_GA_G2_43 Electrocardiogram and arrhythmias, origin of ECG, effects of temperature, ischaemia, infarction and electrolyte imbalance
1_GA_G2_44 Neurological and humoral control of systemic blood pressure, blood volume and blood flow; at rest and during physiological disturbance eg exercise, haemorrhage and Valsalva manoeuvre
1_GA_G2_45 Peripheral circulation: capillaries, vascular endothelium and arteriolar smooth muscle
1_GA_G2_46 Functions of endothelium
1_GA_G2_47 Characteristics of special circulations including pulmonary, coronary, cerebral, renal, portal, transitional and fetal
1_GA_G2_48 Structure and function of renal circulation
1_GA_G2_49 Blood flow and glomerular filtration, plasma clearance and tubule-glomerular feedback

1_GA_G2_50 

Tubular function and urine formation; transport processes in kidney 

1_GA_G2_51 

Assessment of renal function 

1_GA_G2_52 

Regulation of water and electrolyte balance; response to fluid loss/hypovolaemia 

1_GA_G2_53 

Role of urea and creatinine measurement 

1_GA_G2_54 

Regulation of acid-base balance 

1_GA_G2_55 

Pathophysiology of acute kidney injury and renal failure 

1_GA_G2_56 

Gaseous exchange: O2 and CO2 transport, hypoxia and hyper/hypocapnia, hyper and hypobaric pressures 

1_GA_G2_57 

Function of haemoglobin in oxygen carriage and acid-base equilibrium 

1_GA_G2_58 

Pulmonary ventilation: volumes, capacities, flows, dead space, compliance, work of breathing 

1_GA_G2_59 

Effect of IPPV on lungs 

1_GA_G2_60 

Mechanics of ventilation; ventilation/perfusion abnormalities, regional V/Q, surfactant  
1_GA_G2_61 Control of breathing, acute and chronic ventilator failure, effect of oxygen therapy
1_GA_G2_62 Effects of altitude
1_GA_G2_63 Non-respiratory functions of the lungs
1_GA_G2_64 Neuronal structure and function, resting membrane potential, action potentials, conduction, synaptic mechanisms, actions of neurotransmitters
1_GA_G2_65 The brain; functional divisions
1_GA_G2_66 Brain stem: organisation, interconnections. Intracranial pressure, CSF and blood flow
1_GA_G2_67 Autonomic nervous system: organisation, ganglia, adrenergic vs cholinergic
1_GA_G2_68 Neurological reflexes: monosynaptic, polysynaptic, stretch, inhibition
1_GA_G2_69

Motor function: basal ganglia, spinal and peripheral

Sense: receptors, nociception, proprioception, sight, taste, smell, hearing, balance, touch, temperature

1_GA_G2_70 Pain: afferent nociceptive pathways, dorsal horn, peripheral and central mechanisms, neuromodulatory systems, supraspinal mechanisms, visceral pain, neuropathic pain, influence of therapy on nociceptive mechanisms
1_GA_G2_71 Physiology of nausea and vomiting
1_GA_G2_72 Metabolic and digestive functions
1_GA_G2_73 Gastric function: motility, secretions, nausea and vomiting
1_GA_G2_74 Digestive functions: composition of secretions, digestion of carbohydrates, lipids, proteins. Energy homeostasis
1_GA_G2_75 Body mass/composition. Body mass index, body fat estimation
1_GA_G2_76 Principles of nutrition: carbohydrates, fats, proteins, vitamins and minerals
1_GA_G2_77 Energy requirements/expenditure and measurement
1_GA_G2_78 Metabolic pathways, energy production and enzymes, metabolic rate, lactate metabolism
1_GA_G2_79 Hormonal control of metabolism: regulation of plasma glucose, response to trauma
1_GA_G2_80 Physiological alterations in starvation, exercise and the stress response
1_GA_G2_81 Body temperature and its regulation including at extremes of age
1_GA_G2_82 Hormones: types, receptors, hierarchy, extracellular signalling
1_GA_G2_83 Mechanisms of hormonal control: feedback mechanisms, effects on membrane and intracellular receptors
1_GA_G2_84 Hypothalamic and pituitary function
1_GA_G2_85 Adrenocortical hormones
1_GA_G2_86 Adrenal medulla: adrenaline and noradrenaline
1_GA_G2_87 Pancreas: insulin, glucagons and exocrine function
1_GA_G2_88 Thyroid and parathyroid hormones and calcium homeostasis
1_GA_G2_89 Physiological changes associated with pregnancy
1_GA_G2_90 Materno-fetal, fetal and neonatal circulation
1_GA_G2_91 Functions of the placenta; placental transfer


G3: Biochemistry and pharmacology

1_GA_G3_1 Exponential functions including wash-in, wash-out where relevant to anaesthetic practice
1_GA_G3_2 Logarithms relevant to anaesthetic or critical care practice
1_GA_G3_3 Area under the curve (integration) and rate of change (differentiation) relevant to anaesthetic practice
1_GA_G3_4 Organic chemistry: drugs as organic molecules, types of intermolecular bonds, interactions between molecules, organic compared with inorganic compounds, bond strength, important atomic constituents, C, N, O, P, S and halides
1_GA_G3_5 Organic chemistry: ionisation of molecules, types of group that ionise, amides, hydroxyl, carboxyl
1_GA_G3_6 Oxidation and reduction
1_GA_G3_7 Permanently charged (quaternary ammonium) drugs
1_GA_G3_8 Drug chemistry: solubility, partition coefficients and movement of drugs through membranes, lipid solubility, influence of pKa and pH
1_GA_G3_9 Passive and active transport mechanisms
1_GA_G3_10 Isomers: structural and stereo, classification systems, clinical relevance
1_GA_G3_11 Mechanisms of drug action: physicochemical, pharmacodynamics, pharmacokinetic, drug-receptor interactions, dose response and log doseresponse curves, agonists, partial agonists, antagonists
1_GA_G3_12 Reversible and irreversible antagonism. Potency and efficacy
1_GA_G3_13 Non-specific drug actions; physic chemical mechanisms eg adsorption, chelation, neutralisation
1_GA_G3_14  Voltage-gated ion channels, membrane bound transport pumps
1_GA_G3_15 Sodium, potassium and calcium channels as targets for drug action
1_GA_G3_16 Receptors as proteins, ion channels, transmembrane transduction and intermediate messenger systems, intracellular/nuclear receptors
1_GA_G3_17 Receptor regulation and tachyphylaxis
1_GA_G3_18

Response time of ligand gated receptor interaction, enzymes as drug targets,

Michaelis-Menten kinetics

1_GA_G3_19 Direct and allosteric mechanisms eg acetylcholinesterase, cyclo-oxygenase, phosphodiesterase
1_GA_G3_20 Anticholinesterases; classification of drugs that inhibit acetylcholinesterase and plasma cholinesterase including organophosphates
1_GA_G3_21 Predictable side effects of drugs, non selective actions of drugs, action at multiple receptors, multiple anatomical locations, predictable enzyme induction/inhibition
1_GA_G3_22 Idiosyncratic side effects of drugs eg blood and bone marrow dyscrasias, pulmonary fibrosis, antiplatelet effects
1_GA_G3_23 Anaphylactic and anaphylactoid reactions; comparison, treatment, identification of responsible drug, risks of polypharmacy
1_GA_G3_24 Tachyphylaxis and tolerance; examples of drugs demonstrating tachyphylaxis, proposed mechanisms
1_GA_G3_25 Drug interactions: types of interaction, synergism, additivity, antagonism, isobolograms
1_GA_G3_26 Classification of mechanisms of drug interactions
1_GA_G3_27

Pharmacokinetics: general principles – absorption, distribution and redistribution, elimination, excretion. Chemical properties of drugs and their pharmacokinetics. Blood-brain barrier and placental barrier. Protein binding – plasma and tissue. Body compartments, adipose and vessel poor tissue.

Bioavailability, clearance

1_GA_G3_28 Administration and absorption; routes of administration; first pass metabolism and bioavailability. Selection of appropriate route. Drug delivery systems eg sustained release, enteric coated, transdermal patch and iontophoretic systems
1_GA_G3_29 Oral administration: time course for systemic appearance, factors eg pKa, lipid solubility, active transport
1_GA_G3_30 Bioavailability of drugs given orally and its measurement
1_GA_G3_31 Drug elimination from plasma. Mechanisms: distribution, metabolism, excretion, exhalation, renal, biliary, sweat, breast milk
1_GA_G3_32 Factors affecting drug elimination eg pathological state, renal and hepatic failure, age, gender, drug interactions
1_GA_G3_33 Active and inactive metabolites, pro-drugs. Enzyme induction and inhibition
1_GA_G3_34 Non-enzymatic drug elimination. Hofmann degradation
1_GA_G3_35 Pharmacokinetic modelling: types of models available, one, two and three compartment models, non-compartmental, physiological
1_GA_G3_36 Pharmacokinetic parameters: volume of distribution, half-life and time constant, clearance
1_GA_G3_37 Context sensitive half-time: comparison of drugs eg propofol, fentanyl and remifentanil. Target controlled infusions (TCI)
1_GA_G3_38 TCI in practice: accuracy, applicability, cost. Variations due to patient differences – predictable and unpredictable
1_GA_G3_39 Pharmacogenetics: pharmacokinetic variation eg pseudocholinesterase, acetylation, CYP450 variants
1_GA_G3_40 Differences in patient response to therapy: gender, pathology, polypharmacy, changes occurring with increasing age
1_GA_G3_41 Poor and fast metabolisers, racial and geographic distribution of common abnormal genes
1_GA_G3_42 Volatile and gaseous anaesthetic agents: structure of available agents, MAC, clinical effects on CNS, CVS, RS, pharmacokinetics including metabolism
1_GA_G3_43 Mechanisms of general anaesthetic action
1_GA_G3_44 Factors that affect the onset and offset time. Oil/gas partition coefficient. Intravenous anaesthetic agents: chemical classes, properties of an ideal induction agent, adverse effects on CNS, CVS, RS, pharmacokinetics including metabolism
1_GA_G3_45 Benzodiazepines: classification of action, clinical actions, synergism with anaesthetic agents, antidote in overdose
1_GA_G3_46 Local anaesthetic agents. Additional effects including anti-arrhythmic effects. Mechanism of action. Clinical factors influencing choice: operative site, patient, available agents. Toxicity syndrome: safe clinical and maximum clinical doses, treatment of overdose
1_GA_G3_47 Analgesics. Simple analgesics, NSAIDs and opioids. Available routes of administration, perioperative prescribing, chronic compared with acute pain prescribing
1_GA_G3_48 Aspirin and paracetamol. Comparison of structures, indications and contraindications, mechanism of action, bioavailability, metabolism, toxicity
1_GA_G3_49 Non steroidal anti inflammatory analgesics: classification, mechanism of action, clinical effects and uses, unwanted effects, contraindications
1_GA_G3_50 Opioid analgesics: receptor classification, mechanism of action, inhibitory effects, sites of action on pain pathways, unwanted effects, full and partial agonists, routes of administration. Opioid dependence and tolerance
1_GA_G3_51

Muscle relaxants:  Classification. Sites of action. Properties of an ideal muscle relaxant. Dantrolene and management of MH Depolarizing muscle relaxants: Structure, mechanism of action. Organophosphate poisoning Adverse effects and contraindications 

 

1_GA_G3_52 Non-deploarising muscle relaxants: structural classification, sub-classification according to onset time and duration of action. Comparison of aminosteroids and benzylisoquinoliniums. Comparison of individual agents: metabolism and active metabolites. Unwanted effects
1_GA_G3_53 Reversal of neuromuscular blockade: indications for use, mechanism of action, clinically unwanted effects of reversal of neuromuscular blockade
1_GA_G3_54 Drugs and the autonomic nervous system: anatomy, myelinated and unmyelinated nerves, ganglia and rami communicantes
1_GA_G3_55 Neurotransmitters: sites at which drugs and interfere with autonomic transmission
1_GA_G3_56 Drugs and the sympathetic nervous system: adrenergic receptors and molecular mechanisms of action, indications for pharmacological use of naturally occurring and synthetic analogues. Other classes of drugs active in the sympathetic system eg MAOIs
1_GA_G3_57 Drugs and the parasympathetic nervous system: nicotinic and muscarinic receptors with subgroups, mechanism of action agonists and antagonists, comparison of available drugs
1_GA_G3_58 Cardiovascular system: drug effects on the heart and on the circulation, arterial and venous effects, systemic and pulmonary effects
1_GA_G3_59 Inotropes and pressors: classification, site of action, synthetic inotropes compared with adrenaline
1_GA_G3_60 Drugs used in ischaemic heart disease: classification of drugs uses, mechanism of drug action, use in unstable angina
1_GA_G3_61 Antiarrhythmic drugs: classification, indications for use including in resuscitation
1_GA_G3_62 Hypotensive agents: classes of drugs to produce acute hypotension in theatre. Therapeutic antihypertensive agents: classification according to mechanism of action. Adverse effects of drugs in each class
1_GA_G3_63 Anticoagulants: oral and parenteral. Sites of action, indications for use, monitoring effect. Comparison of heparins: unfractionated and fractionated. Newer anticoagulants. Antiplatelet agents. Perioperative management of antiplatelet and anticoagulant medication
1_GA_G3_64 Pro-coagulants: drugs, individual factor concentrates, multifactor preparations including FFP, vitamin K
1_GA_G3_65 Colloids including blood and blood products: composition of preparations, safe use and avoidance of errors
1_GA_G3_66 Crystalloid fluids: composition, suitable fluids for maintenance and replacement of losses. Comparison with colloids, unwanted effects
1_GA_G3_67 Electrolyte solutions including conversion between units eg molar, mg/ml, %
1_GA_G3_68 Respiratory system: classes of drug acting on the respiratory tract including bronchodilators, oxygen, surfactant, mucolytics, pulmonary vasodilators. Methods of administration, indications for use, mechanism of action, adverse effects
1_GA_G3_69 Respiratory system: drugs used in acute severe asthma and chronic asthma, volatile agents, mechanisms of action
1_GA_G3_70 Gastrointestinal system: antisialogogues, drugs reducing gastric acidity, drug effects on the GI tract including gastric and bowel motility
1_GA_G3_71 Applied pharmacology of pro-kinetic and antacids including simple alkalis, H2 receptor antagonists and proton pump inhibitors
1_GA_G3_72 Antiemetics including anatomical sites for antiemetic action, central and peripheral inputs to the vomiting centre, use of dexamethasone
1_GA_G3_73 Renal system: diuretics, classification of diuretics, unwanted effects, indications for use
1_GA_G3_74 CNS: antiepileptic agents, mechanism of action and unwanted effects
1_GA_G3_75 CNS: antidepressants, classes of drug, anaesthetic relevance, toxicity in overdose
1_GA_G3_76 Diabetes mellitus: drugs used in type 1 and type 2 diabetes, insulins: classification, routes of administration. Perioperative management of diabetic therapy. Unwanted effects and risks of hyper/hypo glycaemia and its therapeutic management
1_GA_G3_77 Hormones – corticosteroids: indications for use, clinical effects, long term complications of glucocorticoid use
1_GA_G3_78 Hormones – treatment of thyroid disorders: synthesis and release of thyroid hormones, preparations used in hyper and hypothyroidism
1_GA_G3_79 CNS stimulants: classes, mechanisms of action, uses in anaesthesia
1_GA_G3_80 RS stimulants including theophyllines and doxapram
1_GA_G3_81 Antimicrobial agents: general classification, types of antimicrobial agent, antiviral, antibacterial, antifungal, bacteriostatic and bacteriocidal, mechanisms of action, indications for use of different classes of antibiotics, bacterial resistance
1_GA_G3_82 Effects of drugs on the eye and vision including effect on intra-ocular pressure
1_GA_G3_83 Social and recreational drugs including tobacco, alcohol and non-legal drugs and their anaesthetic relevance


1_GA_H: Provides safe general anaesthesia with distant supervision for ASA 1-3 adults undergoing non-complex elective and emergency surgery within the general theatre setting

 1_GA_H_1

Universal precautions and good working practices for the control of infection including:

  1. Decontaminate hands before treating patient
  2. The use of gloves
  3. The use of sterilised equipment
  4. The disposal of used clinical consumables (single use and reusable)
1_GA_H_2 Pharmacology and pharmacokinetics, including doses, interactions and significant side effects of drugs used during induction of anaesthesia
1_GA_H_3 Management of common problems encountered in patients requiring emergency surgery
1_GA_H_4 Discusses how patients may be inadequately fasted and how this problem is managed
1_GA_H_5 Describes the NCEPOD classifications and explains the importance of these in delivering surgical care to patients


1_GA_I: Describes the specific needs of the obese, frail and elderly patients undergoing general anaesthesia

1_GA_I_1 Anaesthetic management of obese, frail and elderly patients


1_GA_J: Manages intra-operative fluid balance appropriately

1_GA_J_1 Principles of postoperative fluid regimes including volumes, types of fluids and monitoring of fluid balance
1_GA_J_2 Perioperative fluid and feeding


1_GA_K: Can identify patients with difficult airways. Demonstrates management of the ‘cannot intubate cannot oxygenate’ scenario in simulation, and describes difficult airway guidelines

1_GA_K_1 Methods commonly used for assessing the airway to predict difficulty with tracheal intubation, including radiology and its interpretation
1_GA_K_2 Difficult/failed mask ventilation
1_GA_K_3 Failed intubation
1_GA_K_4 Management of the ‘can’t intubate, can’t oxygenate’ scenario
1_GA_K_5 Indications for emergency front of neck access
1_GA_K_6 Conditions that may complicate airway management eg anatomical variation, tumour, bleeding


1_GA_L: Recognises the challenges associated with shared airway surgery

1_GA_L_1 Anaesthetic issues of the shared airway
1_GA_L_2 Specialised devices used to maintain the airway during head and neck surgery
1_GA_L_3 Anaesthetic implications of special surgical devices used during head and neck surgery
1_GA_L_4 Anaesthetic techniques for common ENT and dental procedures; specific anaesthetic issues of ENT and maxilla-facial procedures
1_GA_L_5 Principles of management of bleeding tonsils
1_GA_L_6 Principles of the emergency management of the obstructed airway including tracheostomy
1_GA_L_7 Equipment and safety features associated with the use of LASER


1_GA_M: Provides safe anaesthesia for diagnostic or therapeutic procedures in the non-theatre environment for ASA 1-2 adults with local supervision

1_GA_M_1 Risks and benefits to patients, and risks to staff from common radiological investigations and procedures including the use of contrast media
1_GA_M_2 Awareness of statutory radiological regulations as applied to the referrer, practitioner or operator of diagnostic services
1_GA_M_3

Safe precautions and equipment requirements in specific environments eg

MRI suites

1_GA_M_4 Specific anaesthetic implications of imaging techniques including but not limited to MRI and CT scanning, angiography
1_GA_M_5 Hazards associated with induction of anaesthesia in unusual/remote places eg emergency room and in special circumstances including, but not exclusively, brain injury, full stomach, sepsis, upper airway obstruction


1_GA_N: Explains the principles of anaesthetic care for patients presenting with major trauma

1_GA_N_1 Principles of the perioperative management of the trauma patient
1_GA_N_2 Vascular access in trauma patients including the intraosseous route
1_GA_N_3 Investigations and imaging in trauma
1_GA_N_4 Management of patients with brain injury, including the use of the Glasgow coma scale; mechanisms for the prevention of secondary brain injury
1_GA_N_5 Management of patients with potential cervical spine trauma
1_GA_N_6 Principles of the primary and secondary survey in trauma patients
1_GA_N_7 Pathophysiology associated with trauma
1_GA_N_8 Airway management in the trauma patient including recognition of the compromised airway
1_GA_N_9 Effects of hypothermia in trauma and its prevention


1_GA_O: Explains the principles of paediatric anaesthesia taking into account the anatomical, physiological, psychological and pharmacological differences from adults and their implications for safe practice

1_GA_O_1 Basic sciences specific to children aged one year and above
1_GA_O_2 Preoperative assessment and psychological preparation of children aged one year and above (and their parents) for surgery
1_GA_O_3 Pre-operative fasting in children
1_GA_O_4 Premedication including topical anaesthesia for venepuncture in children
1_GA_O_5 Significance of upper respiratory tract infections and, as a result, when to cancel operations
1_GA_O_6 Obtaining consent for anaesthesia in children


1_GA_P: Provides safe general anaesthesia for ASA 1-2 children 5 years and over with local supervision and 10 years with distant supervision undergoing non-complex elective and emergency surgery

1_GA_P_1 Induction of anaesthesia for children aged 5 years and above
1_GA_P_2 Maintenance of anaesthesia for children aged 5 years and above
1_GA_P_3 Recovery from anaesthesia for children aged 5 years and above
1_GA_P_4 Management of perioperative pain, nausea and vomiting in children including common regional techniques eg caudal
1_GA_P_5 Fluid and electrolyte management in children
1_GA_P_6 Drug dosing in children
1_GA_P_7 Paediatric anaesthetic equipment and the differences from adult practice
1_GA_P_8 Sizing tracheal tubes, supraglottic devices and other airway adjuncts
1_GA_P_9 Breathing systems and the appropriate fresh gas flow rates


1_GA_Q: Explains the anaesthetic implications of pregnancy and undertakes safe general anaesthesia for ASA 1-3 obstetric patients

1_GA_Q_1 The anatomy, physiology and pharmacology related to pregnancy and labour
1_GA_Q_2 Common obstetric indications for anaesthetic intervention of the delivery suite
1_GA_Q_3 The effects of aortocaval compression and how to avoid it
1_GA_Q_4 How to assess fetal well-being in utero
1_GA_Q_5 Local feeding/starvation policies and the reasons behind them
1_GA_Q_6 Thromboprophylaxis requirements in pregnancy
1_GA_Q_7 The grading of urgency of Caesarean section
1_GA_Q_8 Why anaesthetic techniques must be modified in the pregnant patient
1_GA_Q_9 How to access local maternity guidelines and the value of having these guidelines
1_GA_Q_10 Explains the implications of exposing the pregnant or potentially pregnant patient to ionising radiation


1_GA_R: Performs immediate resuscitation and care for patients with acute obstetric emergencies under distant supervision, recognising when additional help is required

1_GA_R_1 The management of pre-eclampsia and eclampsia
1_GA_R_2 Risk factors and management of major obstetric haemorrhage
1_GA_R_3 Modification of ALS guidelines in the pregnant patient


1_GA_S: Describes the principles of total intravenous anaesthesia and uses it safely in clinical practice for non-complex cases

1_GA_S_1 Principles of use of total intravenous anaesthesia